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% \tableofcontents
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\section*{Keywords}
\addcontentsline{toc}{section}{Keywords}
Cancer treatment, drug resistance, chemotherapy resistance, machine learning, artificial intelligence, interpretable machine learning.
\newpage
\section*{Introduction}
\addcontentsline{toc}{section}{Introduction}
Cancer remains one of the leading causes of mortality worldwide, presenting a significant challenge to global health despite considerable advancements in medical research and treatment. According to the data from the International Agency for Research on Cancer (IARC), there were over 19 million new cancer cases and nearly 10 million cancer-related deaths globally in 2020~\cite{cancer}. The high mortality rate is attributed to factors such as late diagnosis, the aggressive nature of certain cancer types, and the complexity of developing effective treatment strategies. The impact of cancer is profound, not only on the patients but also on their families and healthcare systems, underscoring the need for continual improvement in cancer management.